Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity

Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in elongation of very long chain FAs-like 4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Sreemathi Logan, Martin-Paul Agbaga, Michael D. Chan, Richard S. Brush, Robert E. Anderson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2014-04-01
Serie:	Journal of Lipid Research
Soggetti:	mutant lipid metabolism retinal degeneration autosomal dominant elongation of very long chain fatty acids-like 4
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227520376586
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!