ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3

We hypothesized that reduction/loss of very long chain PUFAs (VLC-PUFAs) due to mutations in the ELOngase of very long chain fatty acid-4 (ELOVL4) protein contributes to retinal degeneration in autosomal dominant Stargardt-like macular dystrophy (STGD3) and age-related macular degeneration; hence, i...

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Detalhes bibliográficos

Principais autores:	Man Yu, Aaron Benham, Sreemathi Logan, R. Steven Brush, Md Nawajes A. Mandal, Robert E. Anderson, Martin-Paul Agbaga
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2012-03-01
coleção:	Journal of Lipid Research
Assuntos:	elongase of very long chain fatty acids very long chain polyunsaturated fatty acids chylomicrons fatty acids/biosynthesis juvenile autosomal dominant Stargardt-like macular dystrophy type 3 disease arachidonic acid
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520413641
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