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Efficacy and safety of later-line targeted therapies in advanced non-small cell lung cancer with EGFR exon 20 insertion mutations: a systematic review

BackgroundPlatinum-based chemotherapy and immune checkpoint inhibitors (ICIs) are currently regarded as the standard treatment modalities for advanced non-small cell lung cancer (NSCLC) characterized by EGFR exon 20 insertion (ex20ins) mutations; however, their efficacy is suboptimal. Recent develop...

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Principais autores: Qiang Wen, Yue Zhuang, Silv Fu, Chunguo Pan, Zhihua Liu, Lei Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-12-01
coleção:Frontiers in Pharmacology
Assuntos:
non-small cell lung cancer
EGFR exon 20 insertion mutations
later-line treatment
targeted therapy
systematic review
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1707050/full
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