Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination

IntroductionThe global evolution of resistance to Artemisinin-based Combination Therapies (ACTs) by malaria parasites, will severely undermine our ability to control this devastating disease.MethodsHere, we have used whole genome sequencing to characterize the genetic variation in the experimentally...

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Bibliografische Detailangaben

Hauptverfasser:	Gustavo Capatti Cassiano, Axel Martinelli, Melina Mottin, Bruno Junior Neves, Carolina Horta Andrade, Pedro Eduardo Ferreira, Pedro Cravo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-03-01
Schriftenreihe:	Frontiers in Cellular and Infection Microbiology
Schlagworte:	plasmodium drug resistance artemisinin combination treatment genomics molecular dynamics simulations
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fcimb.2024.1353057/full
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