Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in <i>Aspergillus fumigatus</i>?

Invasive aspergillosis, mainly caused by <i>Aspergillus</i> <i>fumigatus</i>, can lead to severe clinical outcomes in immunocompromised individuals. Antifungal treatment, based on the use of azoles, is crucial to increase survival rates. However, the recent emergence of azole-resistant <i>A. fumigat...

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Váldodahkkit:	Irene Gonzalez-Jimenez, Jose Lucio, Alejandra Roldan, Laura Alcazar-Fuoli, Emilia Mellado
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2021-10-01
Ráidu:	Molecules
Fáttát:	<i>Aspergillus fumigatus</i> <i>hmg1</i> <i>hmg2</i> <i>cyp51A</i> azole resistance mechanisms
Liŋkkat:	https://www.mdpi.com/1420-3049/26/19/5975
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