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Detoxication Strategy of Epoxide Hydrolase—The Basis for a Novel Threshold for Definable Genotoxic Carcinogens

From our recent work on the three-dimensional structure of epoxide hydrolases we theoretically deduced the likelihood of a two-step catalytic mechanism that we and others have subsequently experimentally confirmed. Analysis of the rate of the two steps by us and by others show that the first step—re...

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Autors principals: Franz Oesch, Jan Georg Hengstler, Michael Arand
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publishing 2004-01-01
Col·lecció:Dose-Response
Accés en línia:https://doi.org/10.1080/15401420490426963
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