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Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy

Mutations or triplication of the alpha synuclein (ASYN) gene contribute to synucleinopathies including Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Recent evidence suggests that ASYN also plays an important role in amyloid-induced neurotoxicity, althou...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Suzhen Lin, André D.G. Leitão, Savannah Fang, Yingli Gu, Sophia Barber, Rhiannon Gilliard-Telefoni, Alfredo Castro, Kijung Sung, Ruinan Shen, Jazmin B. Florio, Michael L. Mante, Jianqing Ding, Brian Spencer, Eliezer Masliah, Robert A. Rissman, Chengbiao Wu
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2023-03-01
Rangatū:Neurobiology of Disease
Ngā marau:
Alzheimer's disease
Parkinson's disease
Alpha synuclein
APP
Rab5
Rab7
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S0969996123000244
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