Mismatch prime editing gRNA increased efficiency and reduced indels
Abstract Prime editing enables precise and efficient genome editing, but its efficacy is hindered by pegRNA’s 3’ extension, forming secondary structures due to high complementarity with the protospacer. The continuous presence of the prime editing system also leads to unintended indel formation, rai...
Gardado en:
| Principais autores: | , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2025-01-01
|
| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-024-55578-z |
| Tags: |
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|