ARROW: Allele-Specific Recombined gRNA Design for Reduced Off-Target with Enhanced Specificity
Background/Objectives: Allele-specific genome editing using the CRISPR–Cas9 system is crucial for achieving precise therapeutic interventions in dominant inherited diseases that are otherwise difficult to treat with conventional approaches. However, Cas9–guide RNA (gRNA) complexes often tolerate sin...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2025-11-01
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| coleção: | Bioengineering |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2306-5354/12/11/1237 |
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