Metabolite profiles and DNA methylation in metabolic syndrome: a two-sample, bidirectional Mendelian randomization

Introduction: Metabolic syndrome (MetS) increases the risk of cardiovascular disease and death. Previous ‘-omics’ studies have identified dysregulated serum metabolites and aberrant DNA methylation in the setting of MetS. However, the relationship between the metabolome and epigenome have not been e...

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Autori principali:	Alana C. Jones, Zsuzsanna Ament, Amit Patki, Ninad S. Chaudhary, Vinodh Srinivasasainagendra, Naruchorn Kijpaisalratana, Devin M. Absher, Hemant K. Tiwari, Donna K. Arnett, W. Taylor Kimberly, Marguerite R. Irvin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2023-09-01
Serie:	Frontiers in Genetics
Soggetti:	Mendelian randomization metabolic syndrome metabolomics DNA methylation multiomics
Accesso online:	https://www.frontiersin.org/articles/10.3389/fgene.2023.1184661/full
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