Transmission of reduced levels of miR-34/449 from sperm to preimplantation embryos is a key step in the transgenerational epigenetic inheritance of the effects of paternal chronic social instability stress

The transgenerational effects of exposing male mice to chronic social instability (CSI) stress are associated with decreased sperm levels of multiple members of the miR-34/449 family that persist after their mating through preimplantation embryo (PIE) development. Here we demonstrate the importance...

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Hauptverfasser:	Alexandre Champroux, Yang Tang, David A. Dickson, Alice Meng, Anne Harrington, Lucy Liaw, Matteo Marzi, Francesco Nicassio, Thorsten M. Schlaeger, Larry A. Feig
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2024-12-01
Schriftenreihe:	Epigenetics
Schlagworte:	Epigenetic inheritance miRNAs sperm chronic stress
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/15592294.2024.2346694
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