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Ginger (Zingiber officinale) phytochemicals—gingerenone-A and shogaol inhibit SaHPPK: molecular docking, molecular dynamics simulations and in vitro approaches

Abstract Background Antibiotic resistance is a defense mechanism, harbored by pathogens to survive under unfavorable conditions. Among several antibiotic resistant microbial consortium, Staphylococcus aureus is one of the most havoc microorganisms. Staphylococcus aureus encodes a unique enzyme 6-hyd...

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Principais autores: Shailima Rampogu, Ayoung Baek, Rajesh Goud Gajula, Amir Zeb, Rohit S. Bavi, Raj Kumar, Yongseong Kim, Yong Jung Kwon, Keun Woo Lee
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-04-01
Serier:Annals of Clinical Microbiology and Antimicrobials
Fag:
Ginger phytochemicals
6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase
GOLD
Shogaol
Gingerenone-A
MD simulations
Online adgang:http://link.springer.com/article/10.1186/s12941-018-0266-9
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