Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

In this study, privileged boronic acid ester was introduced into the right wing of etravirine (ETR) to obtain a series of novel boronate-containing derivatives. These newly synthesized derivatives were evaluated for their anti-HIV potency in MT-4 cells using the MTT method, and their inhibitory acti...

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Auteurs principaux:	Da Feng, Hao Lin, Liyang Jiang, Zhao Wang, Yanying Sun, Zhongxia Zhou, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-11-01
Collection:	Molecules
Sujets:	HIV-1 NNRTIs NNIBP DAPY boronate drug design
Accès en ligne:	https://www.mdpi.com/1420-3049/27/21/7538
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