Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design

HIV-1 reverse transcriptase (RT) is responsible for reverse transcription of viral single-stranded RNA to double-stranded DNA, which plays an important role in the replication cycle of HIV-1 and has been identified as a key target for anti-HIV-1 drug discovery. Among HIV-1 RT inhibitors, allosteric...

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Hlavní autoři:	Zhenzhen Zhou, Yanying Sun, Da Feng, Zhao Wang, Fabao Zhao, Shenghua Gao, Peng Zhan, Dongwei Kang, Xinyong Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-01-01
Edice:	Acta Pharmaceutica Sinica B
Témata:	HIV-1 Reverse transcriptase Anti-HIV-1 drugs NNRTIs Structural biology Allosteric inhibitors
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211383525007373
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