Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier

The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders. Here, we demonstrate that the transport of human antibodie...

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Podrobná bibliografie

Hlavní autoři:	Jason Tien, Dmitri Leonoudakis, Ralitsa Petrova, Vivian Trinh, Tetsuya Taura, Debapriya Sengupta, Lisa Jo, Angela Sho, Yong Yun, Eric Doan, Anita Jamin, Hussein Hallak, David S. Wilson, Jennifer R. Stratton
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2023-12-01
Edice:	mAbs
Témata:	Blood-brain barrier (BBB) central nervous system (CNS) immunoglobulin G (IgG) neonatal fc receptor (FcRn) transcytosis Trojan horse
On-line přístup:	https://www.tandfonline.com/doi/10.1080/19420862.2023.2229098
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