Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential

Abstract Background Optimizing the IgG Fc domain for neonatal Fc receptor (FcRn) binding is crucial for enhancing antibody pharmacokinetics. The prolonged serum half-life of IgG antibody is governed by its pH-dependent interaction with FcRn, enabling efficient binding at acidic endosomal pH, intrace...

Description complète

Détails bibliographiques

Auteurs principaux:	Sanghwan Ko, Migyeong Jo, Munsu Kyung, Wonju Lee, Woo Hyung Ko, Jung-Hyun Na, Youn Seo Chun, Byoung Joon Ko, Sang Taek Jung
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-04-01
Collection:	Journal of Biological Engineering
Sujets:	Therapeutic antibody FcRn pH-dependent FcRn binding kinetics Endogenous IgG competition Serum half-life Complement-dependent cytotoxicity
Accès en ligne:	https://doi.org/10.1186/s13036-025-00506-y
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!