mTOR inhibition modulates vaccine-induced immune responses to generate memory T cells in patients with solid tumors

Background Perturbation of the mechanistic target of rapamycin (mTOR) pathway can instruct effector versus memory cell fate of tumor antigen-specific T cells in preclinical models. In this study, we sought to understand the impact of rapamycin (sirolimus), an mTOR inhibitor, on reprogramming vaccine...

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Bibliografiske detaljer

Principais autores:	Li Yan, Nina Bhardwaj, Tibor Keler, Kunle Odunsi, Song Liu, Junko Matsuzaki, Takemasa Tsuji, Mark Long, Thinle Chodon, Emese Zsiros, Protul Shrikant, Jianming Wang, Alan Hutson, Stephanie Blank, Amit Lugade, Richard Koya, Spencer R Rosario, Henry G Withers, Shashikant B Lele
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMJ Publishing Group 2025-03-01
Serier:	Journal for ImmunoTherapy of Cancer
Online adgang:	https://jitc.bmj.com/content/13/3/e010408.full
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