Reprogramming the tumor microenvironment leverages CD8+ T cell responses to a shared tumor/self antigen in ovarian cancer

Tumor antigen-driven responses to weakly immunogenic self-antigens and neoantigens directly affect treatment efficacy following immunotherapy. Using orthotopically grown SV40 T antigen+ ovarian carcinoma in antigen-naive wild-type or TgMISIIR-TAg-Low transgenic mice expressing SV40 T antigen as a se...

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Detalhes bibliográficos

Principais autores:	Anna Mistarz, Marta Winkler, Sebastiano Battaglia, Song Liu, Alan Hutson, Hanna Rokita, Andrea Gambotto, Kunle O. Odunsi, Prashant K. Singh, A.J. Robert McGray, Jianmin Wang, Danuta Kozbor
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-03-01
coleção:	Molecular Therapy: Oncolytics
Assuntos:	immunotherapy ovarian cancer tolerance tumor microenvironment CXCR4 antagonist oncolityc vaccinia virus
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2372770523000104
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