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Brain-specific expression of cytomegalovirus immediate early protein 1 disrupts neurodevelopment in mice by inducing neuroinflammation and altering astrocytic metabolism

Abstract Congenital human cytomegalovirus (HCMV) infection is the leading cause of neurodevelopmental disorders in children, including nongenetic sensorineural hearing loss. Previous studies have shown that HCMV immediate early 1 (IE1) protein, also known as IE72, contributes to brain maldevelopment...

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Principais autores: Meng Yu, Xianjuan Zhang, Zhifei Wang, Shan Wang, Jun Li, Huan Huang, Xu Li, Chen Wang, Wen Shen, Weiwei Sun, Jie Yu, Wanming Zhang, Yunyang Wang, Bin Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-07-01
Serier:Virology Journal
Fag:
Human cytomegalovirus (HCMV)
Immediate early 1 (IE1) protein
Transgenic mouse model
Metabolic reprogramming
Neuroinflammation
Online adgang:https://doi.org/10.1186/s12985-025-02874-9
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