Brain-specific expression of cytomegalovirus immediate early protein 1 disrupts neurodevelopment in mice by inducing neuroinflammation and altering astrocytic metabolism

Abstract Congenital human cytomegalovirus (HCMV) infection is the leading cause of neurodevelopmental disorders in children, including nongenetic sensorineural hearing loss. Previous studies have shown that HCMV immediate early 1 (IE1) protein, also known as IE72, contributes to brain maldevelopment...

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Egile Nagusiak:	Meng Yu, Xianjuan Zhang, Zhifei Wang, Shan Wang, Jun Li, Huan Huang, Xu Li, Chen Wang, Wen Shen, Weiwei Sun, Jie Yu, Wanming Zhang, Yunyang Wang, Bin Wang
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2025-07-01
Saila:	Virology Journal
Gaiak:	Human cytomegalovirus (HCMV) Immediate early 1 (IE1) protein Transgenic mouse model Metabolic reprogramming Neuroinflammation
Sarrera elektronikoa:	https://doi.org/10.1186/s12985-025-02874-9
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