APP‐C31: An Intracellular Promoter of Both Metal‐Free and Metal‐Bound Amyloid‐β40 Aggregation and Toxicity in Alzheimer's Disease

Abstract Intracellular C‐terminal cleavage of the amyloid precursor protein (APP) is elevated in the brains of Alzheimer's disease (AD) patients and produces a peptide labeled APP‐C31 that is suspected to be involved in the pathology of AD. But details about the role of APP‐C31 in the development of...

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Ngā kaituhi matua:	Eunju Nam, Yuxi Lin, Jiyong Park, Hyunsu Do, Jiyeon Han, Bohyeon Jeong, Subin Park, Da Yong Lee, Mingeun Kim, Jinju Han, Mu‐Hyun Baik, Young‐Ho Lee, Mi Hee Lim
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2024-01-01
Rangatū:	Advanced Science
Ngā marau:	accelerator toward amyloidogenesis amyloid precursor protein amyloid‐β metal ions protein–protein interaction
Urunga tuihono:	https://doi.org/10.1002/advs.202307182
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!