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An Injectable Oil-Based Depot Formulation of <i>N</i>-Acyloxymethyl Prodrug of Ropivacaine for Long-Acting Local Analgesia: Formulation Development and In Vitro/In Vivo Evaluation

<b>Objectives:</b> The development of novel long-acting injectables for local anesthetics is necessary to effectively manage the acute postoperative pain. The aim of this study was to prepare an injectable oil-based formulation of ropivacaine (ROP) prodrug (ropivacaine stearoxil, ROP-ST) and to inve...

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Bibliografiske detaljer
Principais autores: Xiaowei Liu, Ruihan Zhao, Peijie Xu, Jianqiang Qian, Peiyan Zhang, Xudong Xie, Yong Ling, Qimin Ge, Yong Chen
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-12-01
Serier:Pharmaceutics
Fag:
Online adgang:https://www.mdpi.com/1999-4923/17/1/37
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