An Injectable Oil-Based Depot Formulation of <i>N</i>-Acyloxymethyl Prodrug of Ropivacaine for Long-Acting Local Analgesia: Formulation Development and In Vitro/In Vivo Evaluation

<b>Objectives:</b> The development of novel long-acting injectables for local anesthetics is necessary to effectively manage the acute postoperative pain. The aim of this study was to prepare an injectable oil-based formulation of ropivacaine (ROP) prodrug (ropivacaine stearoxil, ROP-ST) and to inve...

Повний опис

Бібліографічні деталі

Автори:	Xiaowei Liu, Ruihan Zhao, Peijie Xu, Jianqiang Qian, Peiyan Zhang, Xudong Xie, Yong Ling, Qimin Ge, Yong Chen
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2024-12-01
Серія:	Pharmaceutics
Предмети:	ropivacaine prodrug oil depot long-acting injectables sustained release local analgesia
Онлайн доступ:	https://www.mdpi.com/1999-4923/17/1/37
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!