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The Sphingolipid Inhibitors Ceranib-2 and SKI-II Reduce Measles Virus Replication in Primary Human Lymphocytes: Effects on mTORC1 Downstream Signaling

The bioactive sphingolipids ceramide and sphingosine-1-phosphate (S1P) are involved in the regulation of cell homeostasis and activity ranging from apoptosis to proliferation. We recently described that the two compounds ceranib-2 (inhibiting acid ceramidase) and SKI-II [inhibiting the sphingosine k...

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Principais autores: Janice Chithelen, Hannah Franke, Nora Länder, Anika Grafen, Jürgen Schneider-Schaulies
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-03-01
coleção:Frontiers in Physiology
Assuntos:
acid ceramidase inhibitor ceranib-2
sphingosine kinase inhibitor SKI-II
mTORC1
translation
measles virus
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphys.2022.856143/full
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