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High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase

Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing interest. However, this finding has been mainly...

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Detalhes bibliográficos
Principais autores: Mazen Aseeri, José Luis Abad, Antonio Delgado, Gemma Fabriàs, Gemma Triola, Josefina Casas
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2023-12-01
coleção:Journal of Enzyme Inhibition and Medicinal Chemistry
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Acesso em linha:https://www.tandfonline.com/doi/10.1080/14756366.2022.2150183
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