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C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.

Transcription factors are key regulators of hematopoietic stem cells (HSCs) and act through their ability to bind DNA and impact on gene transcription. Their functions are interpreted in the complex landscape of chromatin, but current knowledge on how this is achieved is very limited. C/EBPα is an i...

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Uloženo v:
Hlavní autoři: Marie S Hasemann, Felicia K B Lauridsen, Johannes Waage, Janus S Jakobsen, Anne-Katrine Frank, Mikkel B Schuster, Nicolas Rapin, Frederik O Bagger, Philipp S Hoppe, Timm Schroeder, Bo T Porse
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2014-01-01
Edice:PLoS Genetics
On-line přístup:http://europepmc.org/articles/PMC3886906?pdf=render
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