C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.

Transcription factors are key regulators of hematopoietic stem cells (HSCs) and act through their ability to bind DNA and impact on gene transcription. Their functions are interpreted in the complex landscape of chromatin, but current knowledge on how this is achieved is very limited. C/EBPα is an i...

Полное описание

Библиографические подробности

Главные авторы:	Marie S Hasemann, Felicia K B Lauridsen, Johannes Waage, Janus S Jakobsen, Anne-Katrine Frank, Mikkel B Schuster, Nicolas Rapin, Frederik O Bagger, Philipp S Hoppe, Timm Schroeder, Bo T Porse
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2014-01-01
Серии:	PLoS Genetics
Online-ссылка:	http://europepmc.org/articles/PMC3886906?pdf=render
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