S1P-S1PR1 signaling impairs CD8+ T cell metabolism and effector function in tumors

Abstract Sphingosine-1-phosphate receptor 1 (S1PR1) signaling has been linked to the regulation of immunosuppressive cell populations within the tumor microenvironment (TME); however, its role in shaping anti-tumor CD8⁺ T cell responses remains poorly defined. Herein, we demonstrate that intratumora...

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Autors principals:	Debashree Basak, Puspendu Ghosh, Anupam Gautam, Ishita Sarkar, Arpita Bhoumik, Soham Chowdhury, Shaun Mahanti, Anwesha Mandal, Rajeswari Chakraborty, Anwesha Kar, Snehanshu Chowdhury, Krishna Kumar, Shubhrajit Barman, Senthil Kumar Ganesan, Saikat Chakrabarti, Sandip Paul, Shilpak Chatterjee
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2026-03-01
Col·lecció:	EMBO Reports
Matèries:	S1P-S1PR1 CD8+ T Cells ER Stress
Accés en línia:	https://doi.org/10.1038/s44319-026-00734-3
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