S1P-S1PR1 signaling impairs CD8+ T cell metabolism and effector function in tumors

Abstract Sphingosine-1-phosphate receptor 1 (S1PR1) signaling has been linked to the regulation of immunosuppressive cell populations within the tumor microenvironment (TME); however, its role in shaping anti-tumor CD8⁺ T cell responses remains poorly defined. Herein, we demonstrate that intratumora...

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Principais autores:	Debashree Basak, Puspendu Ghosh, Anupam Gautam, Ishita Sarkar, Arpita Bhoumik, Soham Chowdhury, Shaun Mahanti, Anwesha Mandal, Rajeswari Chakraborty, Anwesha Kar, Snehanshu Chowdhury, Krishna Kumar, Shubhrajit Barman, Senthil Kumar Ganesan, Saikat Chakrabarti, Sandip Paul, Shilpak Chatterjee
格式:	Artigo
語言:	Inglês
出版:	Springer Nature 2026-03-01
叢編:	EMBO Reports
主題:	S1P-S1PR1 CD8+ T Cells ER Stress
在線閱讀:	https://doi.org/10.1038/s44319-026-00734-3
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