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TonEBP as a key regulator of hypothalamic leptin signaling and resistance

Abstract Tonicity-responsive enhancer binding protein (TonEBP) is a transcription factor implicated in cellular stress and inflammation. Here, we explore the role of TonEBP as a key regulator of leptin signaling and resistance. Using TonEBP haploinsufficient [TonEBP (+/-)] mice, we demonstrated that...

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Principais autores: Han Rae Kim, Dasol Kang, Dong Hee Kim, Bora Jeong, Kwangkon Kim, Byong Seo Park, Hye Rim Yang, Hyug Moo Kwon, Marco Koch, Colin N. Young, Byung Ju Lee, Jae Geun Kim
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2026-03-01
Colecção:Cellular and Molecular Life Sciences
Assuntos:
TonEBP
SOCS3
Hypothalamus
Energy metabolism
Leptin resistance
Acesso em linha:https://doi.org/10.1007/s00018-026-06150-z
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