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MnO2 and roflumilast-loaded probiotic membrane vesicles mitigate experimental colitis by synergistically augmenting cAMP in macrophage

Abstract Background Ulcerative colitis (UC) is one chronic and relapsing inflammatory bowel disease. Macrophage has been reputed as one trigger for UC. Recently, phosphodiesterase 4 (PDE4) inhibitors, for instance roflumilast, have been regarded as one latent approach to modulating macrophage in UC...

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Principais autores: Chengjun Song, Jiamin Wu, Jinhui Wu, Fangyu Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-05-01
Serier:Journal of Nanobiotechnology
Fag:
Membrane vesicles
Roflumilast
MnO2
cAMP
Macrophage
Ulcerative colitis
Online adgang:https://doi.org/10.1186/s12951-024-02558-6
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