Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation

ABSTRACT Merkel cell polyomavirus (MCPyV) is a double-stranded tumor virus that is the main causative agent of Merkel cell carcinoma (MCC). The MCPyV large T antigen (LT), an essential viral DNA replication protein, maintains viral persistence by interacting with host Skp1-Cullin 1-F-box (SCF) E3 ub...

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Bibliografski detalji

Glavni autori:	Alexander M. Pham, Hyun Jin Kwun
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2024-08-01
Serija:	mBio
Teme:	Casein kinase 1α Merkel cell polyomavirus large T persistent infection phosphorylation Skp1-cullin 1-F-box complex
Online pristup:	https://journals.asm.org/doi/10.1128/mbio.01117-24
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