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A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice.

Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunogen displaying domain III (EDIII) of the POWV E glyc...

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Principais autores: Ryan J Malonis, George I Georgiev, Denise Haslwanter, Laura A VanBlargan, Georgia Fallon, Olivia Vergnolle, Sean M Cahill, Richard Harris, David Cowburn, Kartik Chandran, Michael S Diamond, Jonathan R Lai
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2022-06-01
Serier:PLoS Pathogens
Online adgang:https://doi.org/10.1371/journal.ppat.1010573
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