Characterization of virus neuroinvasion, blood-brain barrier integrity and neuroinflammation following Powassan virus infection in mice

Powassan virus (POWV) is a tick-borne Orthoflavivirus transmitted by Ixodes tick species. POWV causes fatal encephalitis in approximately 10-30% of neurological cases, and long-lasting neurological sequelae in approximately 50% of survivors. POWV entry into the central nervous system (CNS) is an imp...

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Principais autores:	Heather Pathak, Amany Elsharkawy, Emilio E. Espínola, Hussin Rothan, Komal Arora, Chinonye Dim, Shannon Stone, Zainab Nabi, Mukesh Kumar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-07-01
coleção:	Frontiers in Immunology
Assuntos:	blood brain barrier encephalitis neuroinflammation orthoflaviviruses powassan virus RNA sequencing
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1813928/full
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