Ponatinib confers adult human cardiomyocyte toxicity via inhibition of AKT signaling

Abstract As a widely used anticancer drug for the treatment of chronic myeloid leukemia, ponatinib is known to cause severe cardiovascular toxicities. Cardiomyocytes are the major functional units in the myocardium, and impairment of their viability and function plays a crucial role in cardiotoxic r...

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Detalhes bibliográficos

Principais autores:	Linna Guo, Rongjia Rao, Hong Liu, Bingying Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-04-01
coleção:	Physiological Reports
Assuntos:	cardiotoxicity human primary cardiomyocytes PI3Kα‐AKT pathway ponatinib
Acesso em linha:	https://doi.org/10.14814/phy2.70877
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