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Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward

CAR T cell qualities, such as persistence and functionality play important roles in determining the outcome of cancer immunotherapy. In spite of full functionality, it has been shown that poor persistence of CAR T cells can limit an effective antitumor immune response. Here, we outline specific stra...

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Бібліографічні деталі
Автори: Leila Jafarzadeh, Elham Masoumi, Keyvan Fallah-Mehrjardi, Hamid Reza Mirzaei, Jamshid Hadjati
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2020-04-01
Серія:Frontiers in Immunology
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Онлайн доступ:https://www.frontiersin.org/article/10.3389/fimmu.2020.00702/full
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