Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward

CAR T cell qualities, such as persistence and functionality play important roles in determining the outcome of cancer immunotherapy. In spite of full functionality, it has been shown that poor persistence of CAR T cells can limit an effective antitumor immune response. Here, we outline specific stra...

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Autori principali:	Leila Jafarzadeh, Elham Masoumi, Keyvan Fallah-Mehrjardi, Hamid Reza Mirzaei, Jamshid Hadjati
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2020-04-01
Serie:	Frontiers in Immunology
Soggetti:	chimeric antigen receptor T cells persistence tumor microenvironment cancer immunotherapy
Accesso online:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00702/full
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