Prognostic significance and therapeutic potential of guanosine triphosphate cyclohydrolase 1 in esophageal squamous cell carcinoma: clinical implications of ferroptosis and lipid peroxidation regulation

BackgroundEsophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is a leading cause of cancer-related death and has a poor prognosis. Despite the advancements in multidisciplinary therapies, resistance to conventional treatments warrants the development of novel therapeutic strat...

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Auteurs principaux:	Masayoshi Sakano, Yoshinobu Tomita, Takumi Kanazawa, Sachiko Ishibashi, Masumi Ikeda, Haruna Oshita, Yuri Hananoi, Yuki Kato, Kurara Yamamoto, Asuka Furukawa, Mayumi Kinoshita, Shigeo Haruki, Masanori Tokunaga, Yusuke Kinugasa, Morito Kurata, Masanobu Kitagawa, Kenichi Ohashi, Kouhei Yamamoto
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2024-12-01
Collection:	Frontiers in Oncology
Sujets:	esophageal squamous cell carcinoma guanosine triphosphate cyclohydrolase 1 ferroptosis lipid peroxidation prognosis therapeutic strategy
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1459940/full
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