Prognostic significance and therapeutic potential of guanosine triphosphate cyclohydrolase 1 in esophageal squamous cell carcinoma: clinical implications of ferroptosis and lipid peroxidation regulation

BackgroundEsophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is a leading cause of cancer-related death and has a poor prognosis. Despite the advancements in multidisciplinary therapies, resistance to conventional treatments warrants the development of novel therapeutic strat...

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Hlavní autoři:	Masayoshi Sakano, Yoshinobu Tomita, Takumi Kanazawa, Sachiko Ishibashi, Masumi Ikeda, Haruna Oshita, Yuri Hananoi, Yuki Kato, Kurara Yamamoto, Asuka Furukawa, Mayumi Kinoshita, Shigeo Haruki, Masanori Tokunaga, Yusuke Kinugasa, Morito Kurata, Masanobu Kitagawa, Kenichi Ohashi, Kouhei Yamamoto
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-12-01
Edice:	Frontiers in Oncology
Témata:	esophageal squamous cell carcinoma guanosine triphosphate cyclohydrolase 1 ferroptosis lipid peroxidation prognosis therapeutic strategy
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1459940/full
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