Restoring brain wiring, mobility, sleep, and lifespan with a novel repurposed modulator of voltage-gated K+ channels: an emerging perspective for channelopathies

Abstract Background Voltage-gated K+ channels (Kv) regulate various essential brain functions. Cognitive impairment, intellectual disability, and sleep disruption are prevalent in Kv1.1- and Kv1.2-related channelopathies, yet the mechanistic basis is unresolved and no symptom-specific repurposing ca...

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Bibliografske podrobnosti

Principais autores:	Maria Dolores Setzu, Maria Antonietta Casu, Ignazia Mocci, Giuseppe Talani, Fatemah M. Haidar, Fabrizio Sanna, Cristina Manis, Pierluigi Caboni, Gilles Bru–Mercier, Francesca Biggio, Manigandan Krishnan, Patrizia Muroni, Bianca Maria Baroli, Roberto Frau, Luca Concas, Monica Puligheddu, Sandeep B. Subramanya, Paola Imbrici, Maria Cristina D’Adamo, Mauro Pessia
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-01-01
Serija:	Journal of Translational Medicine
Teme:	Shaker K+ channels Kv1 T-bar Sleep disturbance Brain wiring Aging Longevity
Online dostop:	https://doi.org/10.1186/s12967-025-07609-6
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