Restoring brain wiring, mobility, sleep, and lifespan with a novel repurposed modulator of voltage-gated K+ channels: an emerging perspective for channelopathies

Abstract Background Voltage-gated K+ channels (Kv) regulate various essential brain functions. Cognitive impairment, intellectual disability, and sleep disruption are prevalent in Kv1.1- and Kv1.2-related channelopathies, yet the mechanistic basis is unresolved and no symptom-specific repurposing ca...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Maria Dolores Setzu, Maria Antonietta Casu, Ignazia Mocci, Giuseppe Talani, Fatemah M. Haidar, Fabrizio Sanna, Cristina Manis, Pierluigi Caboni, Gilles Bru–Mercier, Francesca Biggio, Manigandan Krishnan, Patrizia Muroni, Bianca Maria Baroli, Roberto Frau, Luca Concas, Monica Puligheddu, Sandeep B. Subramanya, Paola Imbrici, Maria Cristina D’Adamo, Mauro Pessia
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-01-01
Serie:	Journal of Translational Medicine
Soggetti:	Shaker K+ channels Kv1 T-bar Sleep disturbance Brain wiring Aging Longevity
Accesso online:	https://doi.org/10.1186/s12967-025-07609-6
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!