Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters

Abstract There is growing demand for improved in vitro liver models to better predict in vivo pharmacology, specifically drug disposition mediated by hepatic transporters and assessment of transporter-mediated drug interaction risk. While 2D sandwich-cultured human hepatocytes (SCHH) remain valuable...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Mattie Hartauer, Henry Ho, Meimei Wan, William A. Murphy, Jacqueline B. Tiley, John K. Fallon, Colin E. Bishop, Kim L. R. Brouwer
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Springer 2025-12-01
Sarja:	Cellular and Molecular Life Sciences
Aiheet:	In vitro model Drug disposition New approach methodologies (NAMs) Bile acids Biliary transport MRP2
Linkit:	https://doi.org/10.1007/s00018-025-05996-z
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