Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters

Abstract There is growing demand for improved in vitro liver models to better predict in vivo pharmacology, specifically drug disposition mediated by hepatic transporters and assessment of transporter-mediated drug interaction risk. While 2D sandwich-cultured human hepatocytes (SCHH) remain valuable...

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Autores principales:	Mattie Hartauer, Henry Ho, Meimei Wan, William A. Murphy, Jacqueline B. Tiley, John K. Fallon, Colin E. Bishop, Kim L. R. Brouwer
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer 2025-12-01
Colección:	Cellular and Molecular Life Sciences
Materias:	In vitro model Drug disposition New approach methodologies (NAMs) Bile acids Biliary transport MRP2
Acceso en línea:	https://doi.org/10.1007/s00018-025-05996-z
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