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Evaluation of the Current ATTR‐CM Treatment Landscape via a Mathematical Model of TTR Dissociation and Amyloid Formation

ABSTRACT Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a progressive, often fatal disease arising from the dissociation of circulating transthyretin (TTR) tetramers into monomers that misfold and form amyloid fibrils that deposit in the myocardium and other tissues. Approved treatment paradigms...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Stevan Methven Jeknić, Travis A. Ahn‐Horst, Alan X. Ji, Jin Hyun Ju, Morgan Paull, Sun‐Gou Ji, Uma Sinha
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Wiley 2026-06-01
Rangatū:CPT: Pharmacometrics & Systems Pharmacology
Ngā marau:
Urunga tuihono:https://doi.org/10.1002/psp4.70277
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