Evaluation of the Current ATTR‐CM Treatment Landscape via a Mathematical Model of TTR Dissociation and Amyloid Formation

ABSTRACT Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a progressive, often fatal disease arising from the dissociation of circulating transthyretin (TTR) tetramers into monomers that misfold and form amyloid fibrils that deposit in the myocardium and other tissues. Approved treatment paradigms...

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Hauptverfasser:	Stevan Methven Jeknić, Travis A. Ahn‐Horst, Alan X. Ji, Jin Hyun Ju, Morgan Paull, Sun‐Gou Ji, Uma Sinha
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2026-06-01
Schriftenreihe:	CPT: Pharmacometrics & Systems Pharmacology
Schlagworte:	biomarkers cardiology mathematical modeling mechanism‐based pharmacokinetics‐pharmacodynamics pharmacometrics systems pharmacology
Online-Zugang:	https://doi.org/10.1002/psp4.70277
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