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Phenotype and functionality of follicular helper T cells in patients with acute dengue infection

Abstract Background The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied. Methods We investigated the phenotype and functionality of Tfh cells and plasmablasts in...

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Hlavní autoři: Ayesha Wijesinghe, Jayani Gamage, Hemantha Goonewardena, Laksiri Gomes, Deshni Jayathilaka, Dulharie T. Wijeratne, Ruklanthi de Alwis, Chandima Jeewandara, Ananda Wijewickrama, Graham S. Ogg, Gathsaurie Neelika Malavige
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2020-04-01
Edice:Journal of Biomedical Science
Témata:
Follicular helper T cells
Plasmablasts
IL-21
Neutralizing antibodies
NS1 antibodies
Viral loads
On-line přístup:http://link.springer.com/article/10.1186/s12929-020-00641-2
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