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Profiling parvalbumin interneurons using iPSC: challenges and perspectives for Autism Spectrum Disorder (ASD)

Abstract Autism spectrum disorders (ASD) are persistent conditions resulting from disrupted/altered neurodevelopment. ASD multifactorial etiology—and its numerous comorbid conditions—heightens the difficulty in identifying its underlying causes, thus obstructing the development of effective therapie...

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Principais autores: Federica Filice, Beat Schwaller, Tanja M. Michel, Edna Grünblatt
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-01-01
Serier:Molecular Autism
Fag:
Parvalbumin
Induced pluripotent stem cells
Autism spectrum disorder
Schizophrenia
CRISPR-Cas9 technology
GABAergic
Online adgang:https://doi.org/10.1186/s13229-020-0314-0
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