Development of a nonhuman primate challenge model to evaluate CD8+ T cell responses to an adenovirus-based vaccine expressing SIV proteins upon repeat-dose treatment with checkpoint inhibitors

Targeting immune checkpoint receptors expressed in the T cell synapse induces active and long-lasting antitumor immunity in preclinical tumor models and oncology patients. However, traditional nonhuman primate (NHP) studies in healthy animals have thus far demonstrated little to no pharmacological a...

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Detalhes bibliográficos

Principais autores:	Richard Graveline, Morad Haida, Carolyne Dumont, Dominic Poulin, Florence Poitout-Belissent, Rana Samadfam, Sven Kronenberg, Franziska Regenass-Lechner, Rodney Prell, Marie-Soleil Piche
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2022-01-01
coleção:	mAbs
Assuntos:	cd8 t cell function adenovirus nonhuman primate siv antigen challenge checkpoint inhibitors
Acesso em linha:	http://dx.doi.org/10.1080/19420862.2021.1979447
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