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The novel antitumor compound clinopodiside A induces cytotoxicity via autophagy mediated by the signaling of BLK and RasGRP2 in T24 bladder cancer cells

In the study, we investigated the anti-cancer effect of clinopodiside A and the underlying mechanisms using T24 bladder cancer cells as an experimental model. We found that the compound inhibited the growth of the bladder cancer cells in vitro and in vivo in a in a concentration- and dose-dependent...

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Principais autores: Rong Sheng Zhou, Ji Zhong Zhao, Li Ming Guo, Jia Li Guo, Aida El Makawy, Zong Yun Li, Shao Chin Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-09-01
coleção:Frontiers in Pharmacology
Assuntos:
clinopodiside A
autophagy
apoptosis
BLK
RasGRP2
combinational effect
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.982860/full
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