Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites
Zidovudine (AZT), the first drug approved by the US Food and Drug Administration for the treatment of human immunodeficiency virus (HIV) infection, is metabolized in the host cells to 5′-AZT triphosphate (AZT-TP) which inhibits HIV reverse transcriptase. As the pharmacokinetics of AZT and its phosph...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier
2016-03-01
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| Серии: | Acta Pharmaceutica Sinica B |
| Предметы: | |
| Online-ссылка: | http://www.sciencedirect.com/science/article/pii/S2211383515001434 |
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